Three simple spectrophotometric methods have been developed for simultaneous estimation of Ibuprofen (IBU) and Famotidine (FAM) from tablet dosage form. Methanol (A.R. grade) was used as solvent. First method, multi-component mode of analysis (Method A), involves the measurement of absorbances at two wavelengths 264.0 nm (λmax of IBU) and 287.0 nm (λmax of FAM). Second method, Derivative spectroscopy (Method B), wavelength selected for quantitation were 287 nm (zero crossing point for IBU) for FAM in zero order derivative mode and 249 nm (zero crossing point for FAM) for IBU in third order derivative mode. Third method, Dual wavelength method (Method C), difference in absorbance at 264 nm and 306.5 nm give direct estimation of IBU in bulk and combined dosage form. The linearity lied between 200-1000 µg/ml and 2-10 µg/ml for IBU and FAM respectively for Method A, 200-500 µg/ml and 4-10 µg/ml for IBU and FAM respectively for Method B and 200-500 µg/ml for IBU for Method C. The accuracy and precision of the methods were determined and validated statically. The proposed methods were found to be rapid, specific, precise, and accurate and can be successfully applied for the routine analysis of Ibuprofen and Famotidine in bulk and combined dosage form.
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